Antibiotic History and MRSA in Children
William T. Basco, Jr., MD, MS
Authors and Disclosures
Antibacterial Drugs and the Risk of Community-Associated Methicillin-Resistant Staphylococcus aureus in Children
Schneider-Lindner V, Quach C, Hanley JA, Suissa S
Arch Pediatr Adolesc Med. 2011;165:1107-1114
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an increasing problem. Although most CA-MRSA infections involve the skin and soft tissue, CA-MRSA can also cause devastating invasive disease. Other investigators have examined different risk factors for children acquiring a CA-MRSA infection, but none have previously explored the relationship between antibiotic exposure and risk of developing infection with CA-MRSA. This study used existing data from the General Practice Research Database of the United Kingdom, which includes prescription data from over 400 general practices. Participants were 0-19 years of age and had been seen between 1993 and 2007. The investigators first identified cases of CA-MRSA using administrative diagnostic codes, and then reconstructed the children's medical histories to evaluate previous medical diagnoses and prescriptions. Cases were matched with controls using month and year of birth.