Occurrence of Clostridium botulinum neurotoxin in chronic disease of dairy cows
Christian Seyboldt,Sabrina Discher,Eva Jordan,Heinrich Neubauer,Katharina Charlotte Jensen,Amely Campe,Lothar Kreienbrock,Theresa Scheu,Anika Wichern,Frieder Gundling,Phuong DoDuc,Svenja Fohler,Amir Abdulmawjood,G?nter Klein,Martina Hoedemaker Veterinary Microbiology
Volume 177, Issues 3?4, 12 June 2015, Pages 398?402
Highlights
?A case-control study was conducted to test the hypothesis of visceral botulism. ?BoNT in the feces of affected animals is the main point of the hypothesis. ?Fecal samples of 1388 animals were tested for the presence of BoNT. ?BoNT was not detected in any of the fecal samples. ?The hypothesis of visceral botulism could not be proven.
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In addition to foodborne botulism in domestic animals, another form of disease in cattle has been discussed controversially. An untypical form of botulism is supposed to be caused by the colonization of the lower intestine with C. botulinum bacteria, subsequent production of BoNT and continuous resorption of small amounts of toxins resulting in chronic wasting of the affected dairy herd involving a complex of unspecific clinical symptoms, reduced performance and massive animal losses ( Bohnel et al., 2001). The presumed trigger is a microbial imbalance in the digestive tract favoring the multiplication and toxin production of C. botulinum. It is assumed that this syndrome is multifactorial. This hypothesis has been proposed as ?visceral? form of botulism ( Bohnel et al., 2001). Especially, a significant number of dairy herds affected by chronic wasting condition in Northern Germany were suspected to suffer from ?visceral? botulism ( Bohnel and Gessler, 2012). Due to the unspecific clinical picture, a reasonable case definition based on clinical findings is still pending. ?Visceral? botulism was also discussed to be a sporadic, but severe zoonosis, when farmers or members of their families developed illness involving neurological syndromes (Dressler and Saberi, 2009)...
Christian Seyboldt,Sabrina Discher,Eva Jordan,Heinrich Neubauer,Katharina Charlotte Jensen,Amely Campe,Lothar Kreienbrock,Theresa Scheu,Anika Wichern,Frieder Gundling,Phuong DoDuc,Svenja Fohler,Amir Abdulmawjood,G?nter Klein,Martina Hoedemaker Veterinary Microbiology
Volume 177, Issues 3?4, 12 June 2015, Pages 398?402
Highlights
?A case-control study was conducted to test the hypothesis of visceral botulism. ?BoNT in the feces of affected animals is the main point of the hypothesis. ?Fecal samples of 1388 animals were tested for the presence of BoNT. ?BoNT was not detected in any of the fecal samples. ?The hypothesis of visceral botulism could not be proven.
...
In addition to foodborne botulism in domestic animals, another form of disease in cattle has been discussed controversially. An untypical form of botulism is supposed to be caused by the colonization of the lower intestine with C. botulinum bacteria, subsequent production of BoNT and continuous resorption of small amounts of toxins resulting in chronic wasting of the affected dairy herd involving a complex of unspecific clinical symptoms, reduced performance and massive animal losses ( Bohnel et al., 2001). The presumed trigger is a microbial imbalance in the digestive tract favoring the multiplication and toxin production of C. botulinum. It is assumed that this syndrome is multifactorial. This hypothesis has been proposed as ?visceral? form of botulism ( Bohnel et al., 2001). Especially, a significant number of dairy herds affected by chronic wasting condition in Northern Germany were suspected to suffer from ?visceral? botulism ( Bohnel and Gessler, 2012). Due to the unspecific clinical picture, a reasonable case definition based on clinical findings is still pending. ?Visceral? botulism was also discussed to be a sporadic, but severe zoonosis, when farmers or members of their families developed illness involving neurological syndromes (Dressler and Saberi, 2009)...
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