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Study could not find evidence to support theory that chronic botulism is causing emerging wasting disease in dairy cows that may have caused neurological illness in farm families

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  • Study could not find evidence to support theory that chronic botulism is causing emerging wasting disease in dairy cows that may have caused neurological illness in farm families

    Occurrence of Clostridium botulinum neurotoxin in chronic disease of dairy cows
    Christian Seyboldt,Sabrina Discher,Eva Jordan,Heinrich Neubauer,Katharina Charlotte Jensen,Amely Campe,Lothar Kreienbrock,Theresa Scheu,Anika Wichern,Frieder Gundling,Phuong DoDuc,Svenja Fohler,Amir Abdulmawjood,Günter Klein,Martina Hoedemaker Veterinary Microbiology
    Volume 177, Issues 3–4, 12 June 2015, Pages 398–402
    Highlights

    •A case-control study was conducted to test the hypothesis of visceral botulism. •BoNT in the feces of affected animals is the main point of the hypothesis. •Fecal samples of 1388 animals were tested for the presence of BoNT. •BoNT was not detected in any of the fecal samples. •The hypothesis of visceral botulism could not be proven.


    ...
    In addition to foodborne botulism in domestic animals, another form of disease in cattle has been discussed controversially. An untypical form of botulism is supposed to be caused by the colonization of the lower intestine with C. botulinum bacteria, subsequent production of BoNT and continuous resorption of small amounts of toxins resulting in chronic wasting of the affected dairy herd involving a complex of unspecific clinical symptoms, reduced performance and massive animal losses ( Bohnel et al., 2001). The presumed trigger is a microbial imbalance in the digestive tract favoring the multiplication and toxin production of C. botulinum. It is assumed that this syndrome is multifactorial. This hypothesis has been proposed as “visceral” form of botulism ( Bohnel et al., 2001). Especially, a significant number of dairy herds affected by chronic wasting condition in Northern Germany were suspected to suffer from “visceral” botulism ( Bohnel and Gessler, 2012). Due to the unspecific clinical picture, a reasonable case definition based on clinical findings is still pending. “Visceral” botulism was also discussed to be a sporadic, but severe zoonosis, when farmers or members of their families developed illness involving neurological syndromes (Dressler and Saberi, 2009)...
    http://www.sciencedirect.com/science...78113515001169
    __________________________________________________ _______________________________
    "Well, now." Mr. Summers said soberly, "guess we better get started, get this over with, so's we can go
    back to work. Anybody ain't here?" ---The Lottery by Shirley Jackson

    “‘i love myself.’ the quietest. simplest. most powerful. revolution ever.” ---- nayyirah waheed

    (My posts are not intended as advice or professional assessments of any kind.)
    Never forget Excalibur.

  • #2
    I wonder if the research below is related.

    http://www.omicsonline.org/open-acce....php?aid=39228
    Gerlach et al., J Environ Anal Toxicol 2014, 5:2
    http://dx.doi.org/10.4172/2161-0525.1000256
    Oral Application of Charcoal and Humic Acids Influence Selected
    Gastrointestinal Microbiota, Enzymes, Electrolytes, and Substrates in the
    Blood of Dairy Cows Challenged with Glyphosate in GMO Feeds

    Henning Gerlach1, Achim Gerlach2, Wieland Schrödl1, Svent Haufe4, Bernd Schottdorf3, Awad A. Shehata1,5 and Monika Krüger1*
    1Institute of Bacteriology and Mycology, Veterinary Faculty, University of Leipzig, An den Tierkliniken 29, D-04103 Leipzig, Germany
    2Waldstraße 78, D-25712 Burg, Germany
    3Carbon Terra GmbH Gutermannstrasse 25, D-86154 Augsburg, Germany
    4WH Pharmawerk Weinböhla GmbH, Poststr. 58, D-01689 Weinbohla, Germany
    5Avian and Rabbit Diseases Department, Faculty of Veterinary Medicine, Sadat City University, Egypt

    Abstract
    The present study was initiated to investigate the influence of oral application of charcoal, sauerkraut juice and
    humic acids on specific gastrointestinal microbiota and selected enzymes, electrolytes, and substrates in the blood of
    dairy cows fed GMO feeds containing glyphosate. A total of 380 Schleswig Holstein cows suffering from symptoms of
    chronic botulism
    were fed sequentially with 400 g/animal charcoal daily for 4 weeks (weeks 1-4 of the study), 200 g/
    animal charcoal (weeks 5-10 of the study), 200 g charcoal and 500 ml Sauerkraut juice/animal (weeks 11-14 of the
    study), 120 g/animal humic acids (weeks 15-18 of the study) 200 g charcoal and 100 mL Aquahumin/animal (weeks 19-
    20 the of study), or 100 g charcoal and 50 mL Aquahumin (weeks 21-22 of the study) followed by 4 weeks without any
    supplementation. There was a significant reduction of glyphosate in urine following supplementation with a combination
    of 200g charcoal plus either 500 mL sauerkraut juice or humic acid. From all of the parameters investigated in blood
    and urine, distinctive effects were only seen as a lack of manganese and cobalt and a significant reduction of creatinine
    excretion by urine. All other measured parameters such as creatine kinase (CK), alkaline phosphatase (AP), glutamate
    dehydrogenase (GLDH), glutamate oxaloacetate transaminase (GOT), and cholesterol, urea, and blood creatinine)
    were not significantly changed. A significant increase of fecal Gram-negative bacteria and enterococci were only seen
    at week 8 (200 g charcoal/d) and week 20 (200 g charcoal+100 mL Aquahumin). In conclusion, a charcoal-sauerkraut
    juice combination and humic acids reduced glyphosate excretion by urine and led to the improved health of animals
    .
    __________________________________________________ _______________________________
    "Well, now." Mr. Summers said soberly, "guess we better get started, get this over with, so's we can go
    back to work. Anybody ain't here?" ---The Lottery by Shirley Jackson

    “‘i love myself.’ the quietest. simplest. most powerful. revolution ever.” ---- nayyirah waheed

    (My posts are not intended as advice or professional assessments of any kind.)
    Never forget Excalibur.

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