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Coronavirus syndrome seen in UK Children

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  • Coronavirus syndrome seen in UK Children

    The report, by the Health Service Journal, refers to an ‘urgent alert’ issued to doctors about the new syndrome, following a rise in cases over the last few weeks.

    According to HSJ, the alert said: “[In the] last three weeks, there has been an apparent rise in the number of children of all ages presenting with a multisystem inflammatory state requiring intensive care across London and also in other regions of the UK.

    “There is a growing concern that a [covid-19] related inflammatory syndrome is emerging in children in the UK, or that there may be another, as yet unidentified, infectious pathogen associated with these cases.”

    The syndrome, which is yet to be named, can cause several unpleasant symptoms, including abdominal pain and cardiac inflammation, according to the report.

    “The only security we have is our ability to adapt."

  • #2
    Children affected by the new condition have "overlapping features of toxic shock syndrome and atypical Kawasaki disease". Kawasaki disease is a rare illness that largely affects children under five and involves the swelling of blood vessels in the body. It can trigger a temperature, rash or swollen glands in the neck.

    The illness has been discovered in children who tested positive to the virus, as well as those who have not. There is also some evidence of "possible preceding" Covid-19 infection in some children.

    "Therefore given we've got a new presentation of this at the time of a new disease, the possibility ... that there is a link is certainly plausible. But numbers are very small and the key thing is that if parents are worried, phone up and get advice."


    • #3
      NHS England said it knew of fewer than 20 such cases in the country where an association has been noted by clinicians. Investigations will continue, but no link has yet been established, said a spokesman.

      Dr Nazima Pathan, a consultant in Paediatric Intensive Care in Cambridge, said colleagues in Spain and Italy had been reporting similar cases...


      • #4

        Transcript of daily media conference 28 April 2020

        : What advice have you received about these larger blood vessel clots and strokes that younger people appear to be having who have had COVID-19?

        Dr Ashley Bloomfield: I haven’t received any advice, but what I can say is we’re keeping a really close eye on any emerging reports around clinical presentations that have been—this is one—in the last week, these reports around vascular and blood changes. There’s also an emerging report from the UK just today around the possibility of a—there’s only a small number of children with Kawasaki disease and some of these have been COVID-19 positive, others haven’t. Again, a small number. So these are the sorts of things we are looking at on a daily basis just to see, is this something we need to advise our clinicians about, to look for. So what does seem to be clear is that this infection, even though it’s a respiratory infection, does affect other organ systems and, as we learn more about it, that will inform both how we manage people, and then, of course, also it will identify groups that might be a high risk that we need to act on.

        Media: And does it serve as a reminder as well for younger people, because I think those strokes have all occurred in people who are under 50 years old, that isn’t just a virus that disproportionately hurts older people or people with underlying health conditions?

        Dr Ashley Bloomfield: Quite. It’s not just confined to those groups, and we’ve seen in New Zealand our biggest groups, in terms of age groups that have been infected, largely reflecting people coming back from overseas in the nature of some of our clusters. The biggest groups have been 20- to 40-year-olds. They’re not as susceptible to the poor outcomes, but it doesn’t mean that they don’t get those, and we’ve seen overseas where you have high numbers of cases, you do see some of these people get very unwell and some of them die. And even in the UK in that report around Kawasaki disease I was reading today, they have had a small number of deaths in under-20-year-olds related to COVID-19. It is not an innocuous infection in any age group.


        • #5
          Nearly 100 cases of the unusual illness have emerged in at least six countries, with doctors in Britain, the US, France, Italy, Spain and Switzerland now reported to be investigating the condition.

          So far 19 children have been affected in the UK and none have died.

          Veran told Franceinfo news radio he had received an alert from Paris concerning “about 15 children of all ages

          At least three children in the US aged six months to eight years are being treated for a similar condition.


          • #6
            Google translation from Italian

            doctors of the Papa Giovanni XIII hospital in Bergamo noticed an anomalous increase in cases they thought there could be a correlation between the arrival of children with the symptoms of the pathology and Sars Cov 2 in the emergency room.

            In a month equaled the number of cases of three previous years - "In the last two months - adds Pope John Pediatrician rheumatologist Lucio Verdoni -, we realized that several children who had a disease known as Kawasaki disease came to the pediatric emergency room . In a month the number of cases matched those seen in the previous three years . It has been calculated that the incidence of this disease in the last month has been 30 times higher than in the past ".

            Importantly, only a small minority of children infected with SARS-CoV-2 develop Kawasaki disease, certainly less than 1%



            • #7
              Reports also came from France, Belgium and the United States, reports RSI.


              Fifteen or twenty cases, affecting children aged 2 to 15 years, have already been identified in France.

              More than a dozen patients aged 5 to 12 are hospitalized at Necker Hospital, without any comorbidity. We cannot speak of an influx, but we have a significant number of patients who present the same symptoms ” , explains to Le Monde Professor Mehdi Oualha, pediatric resuscitator at Necker.

              four children under the age of 10 are or have been hospitalized in intensive care units in Robert-Debré, three in Trousseau, five or six in Bicêtre.



              • #8
                Similar cases have also been reported in Belgium, Italy, Spain , the United States and Australia .

                The number of children is low: we are talking about 25 cases in Île-de-France, 10 cases in Belgium, three in the United States. No fatal case has yet been identified, says Midi Libre


                But the Health Secretary (UK) has today said "we have lost some children" to a disease "we think is caused by the coronavirus".

                Speaking on LBC radio, Mr Hancock said: "We have lost some children," he said, adding: "There are some children who have died who didn't have underlying health conditions."

                Mr Hancock explained: "It's a fresh, new disease that we think may be caused by coronavirus and the Covid-19 virus.


                The World Health Organisation (WHO) said it had asked its global networks of clinicians to be on “alert” for the rare phenomenon,



                • #9
                  about twenty children ", " from 2 to 18 years ", confirms Damien Bonnet, head of pediatric cardiology department at Necker hospital for sick children. " According to my French colleagues, there are others elsewhere, " he adds, stressing however that their number in absolute terms " remains limited ". " Most of them need to be helped with drugs to support the functioning of the heart, " explains Professor Bonnet. " The children almost all evolve in a favorable way, even if they are in a resuscitation situation initially, " he reassures.

                  According to this specialist in infectious diseases, the phenomenon is not new. " This is something we have at this time of year, in the spring period ," he observes. "We already had Kawasaki or "Kawasaki-like" in April, May, June and July. There is no identified cause, it is probably something multifactorial, with a predisposition of the patient and a viral trigger. Maybe the virus that is currently circulating is triggering something. But there may also be environmental factors, linked for example to pollution. "

                  Professor Isabelle Kone Paut, head of the national Kawasaki disease surveillance network, adds a nuance to Franceinfo : the usual treatment" does not seem sufficient to avoid the inflammatory runaway in the cases reported.



                  • Emily
                    Emily commented
                    Editing a comment
                    Industrial pollution seems to be lower during the lockdowns, so it would have to local pollution by neighborhood wood or waste fires from people being home and acting anti-social if pollution is causing an increase in Kawasaki. Maybe it's adjuvanting the viral effect on the immune system.

                • #10
                  Professor Jones of Virology at the University of Reading in the United Kingdom pointed out that there are studies that human coronavirus NL63 is related to Kawasaki disease, and both NL63 virus and the new coronavirus that broke out this year use the ACE2 receptor on the surface of the cell membrane to enter the body.
                  But he believes that it is still too early to say that the new coronavirus is related to Kawasaki disease.


                  • #11

                    Warning of viral myocarditis in children and young people - caused by colds and other viruses - symptoms including fever fatigue and skin rash.

           Tuesday, January 7th, 2020

                    Sister Wang, a cute little girl of 2 years old, had a continuous fever for 3 to 4 days. When it burned, it burned to 39 degrees. When I took it to the clinic, there was no obvious improvement. The pediatrics of Keelung Hospital of the Ministry of Health and Welfare, the chief physician Xie Wanghu diagnosed Sister Wang as Kawasaki disease and must be hospitalized immediately.
                    No word of testing for coronavirus at this date.
                    “The only security we have is our ability to adapt."


                    • #12
                      12.2 children per 100,000 under the age of 5 was the latest count 2016/17 in England.

                      Megan Rutter, Peter C Lanyon, Mary Bythell, Sarah Stevens, Jeanette Aston, Fiona A Pearce, P134 Collaborating with the National Congenital Anomaly and Rare Disease Registration Service to estimate national incidence of Kawasaki disease in England, Rheumatology, Volume 59, Issue Supplement_2, April 2020, keaa111.129,

                      The true incidence of Kawasaki disease (KD) in England is unknown. In KD treatment with intravenous immunoglobulin (IVIG) can be lifesaving, but it is both expensive and in limited supply. In collaboration with Public Health England’s National Congenital Anomaly and Rare Disease Registration Service (NCARDRS) we aimed to determine the incidence of KD in England.
                      Never forget Excalibur.
                      “‘i love myself.’ the quietest. simplest. most powerful. revolution ever.” ---- nayyirah waheed
                      Avatar: Franz Marc, Liegender Hund im Schnee 1911 (My posts are not intended as advice or professional assessments of any kind.)


                      • #13
                        Statement from the The UK Kawasaki Disease Foundation

                        Based on all available information made available so far we note:

                        The cases being referred to have been reported in approximately 20 children in the UK (out of 11.5 million U.K. children) – of whom half tested *negative* for Covid-19 according to their doctors.

                        There is no current evidence of any increased incidence or greater susceptibility to Covid-19 infection for children who had Kawasaki Disease in the past.

                        All of the c. 20 cases are new, acute illness in children.

                        Fewer cases of Kawasaki Disease than would be normally expected at this time of year are currently being seen – not more.