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China - Original 2019-nCov news thread: weeks 1 - 4 (December 30, 2019 - January 25, 2020)

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  • Spring Festival will not be affected by new coronavirus

    CCTV News reported on January 9 that recently, the "culprit" of unexplained pneumonia in Wuhan was initially identified as a new type of coronavirus. Will the safety of the Spring Festival travel be threatened? At a press conference held by the State Council Office today (9th), heads of various departments including the Ministry of Transport, the State Railway Administration, and China National Railway Group Co., Ltd. said that the Spring Festival Transport will not be affected.

    https://m.thepaper.cn/newsDetail_forward_5471125

    Comment


    • Source: https://www.statnews.com/2020/01/09/...nment-efforts/

      Chinese scientists obtain genetic sequence of mysterious virus, a key step in containment efforts
      By Helen Branswell
      January 9, 2020

      Chinese scientists have recovered a previously unknown virus from an infected individual and generated a full genetic sequence of it, a key step in efforts to learn more about the cause of an outbreak of unusual pneumonia in the city of Wuhan, state-run media reported Thursday.

      Fragments of the same virus were picked up in testing of 15 patients among the 59 who have been identified as infected with the mysterious pneumonia.

      The speed of the findings is impressive; the first case in this outbreak became ill less than a month ago...

      ...Confirmation that scientists have the genetic sequence of the virus will increase pressure on China to release at least part of that sequence, so that health facilities around the world know what to look for as they try to detect possible cases from this outbreak...

      Comment


      • WHO Statement Regarding Cluster of Pneumonia Cases in Wuhan, China

        9 January 2020 Statement China

        Chinese authorities have made a preliminary determination of a novel (or new) coronavirus, identified in a hospitalized person with pneumonia in Wuhan. Chinese investigators conducted gene sequencing of the virus, using an isolate from one positive patient sample. Preliminary identification of a novel virus in a short period of time is a notable achievement and demonstrates China’s increased capacity to manage new outbreaks.

        Initial information about the cases of pneumonia in Wuhan provided by Chinese authorities last week – including the occupation, location and symptom profile of the people affected – pointed to a coronavirus (CoV) as a possible pathogen causing this cluster. Chinese authorities subsequently reported that laboratory tests ruled out SARS-CoV, MERS-CoV, influenza, avian influenza, adenovirus and other common respiratory pathogens.

        Coronaviruses are a large family of viruses with some causing less-severe disease, such as the common cold, and others more severe disease such as MERS and SARS. Some transmit easily from person to person, while others do not. According to Chinese authorities, the virus in question can cause severe illness in some patients and does not transmit readily between people.

        Globally, novel coronaviruses emerge periodically in different areas, including SARS in 2002 and MERS in 2012. Several known coronaviruses are circulating in animals that have not yet infected humans. As surveillance improves more coronaviruses are likely to be identified.

        China has strong public health capacities and resources to respond and manage respiratory disease outbreaks. In addition to treating the patients in care and isolating new cases as they may be identified, public health officials remain focused on continued contact tracing, conducting environmental assessments at the seafood market, and investigations to identify the pathogen causing the outbreak.

        In the coming weeks, more comprehensive information is required to understand the current status and epidemiology of the outbreak, and the clinical picture. Further investigations are also required to determine the source, modes of transmission, extent of infection and countermeasures implemented. WHO continues to monitor the situation closely and, together with its partners, is ready to provide technical support to China to investigate and respond to this outbreak.

        The preliminary determination of a novel virus will assist authorities in other countries to conduct disease detection and response. Over the past week, people with symptoms of pneumonia and reported travel history to Wuhan have been identified at international airports.

        WHO does not recommend any specific measures for travellers. WHO advises against the application of any travel or trade restrictions on China based on the information currently available.

        https://www.who.int/china/news/detai...in-wuhan-china
        "Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear."
        -Nelson Mandela

        Comment


        • New coronavirus! Preliminary ruling on unexplained pneumonia in Wuhan
          CCTV News Client CCTV News Client January 9, 2020 08:13A-A +

          Regarding the progress of the pathogenic identification of unexplained viral pneumonia epidemic in Wuhan, the reporter learned from the expert group of preliminary assessment of pathogenic test results today that as of 21:00 on January 7, 2020, a new type of coronavirus was detected in the laboratory and obtained The whole genome sequence of the virus was detected by nucleic acid detection method in a total of 15 cases of new coronavirus positive results. The virus was isolated from a positive patient sample and showed typical coronavirus appearance under electron microscope.

          The expert group believes that the pathogen of this unexplained case of viral pneumonia was initially identified as a new type of coronavirus.

          Tissue laboratories use genomic sequencing, nucleic acid detection, virus isolation, and other methods to etiologically detect samples from patients with alveolar lavage fluid, throat swabs, and blood.

          The expert group stated that the identification of the cause of an epidemic usually requires the following:

          (1) Suspicious pathogens must be found in patients, and pathogenic nucleic acids can be detected in clinical samples of patients;

          (2) The pathogen can be successfully isolated from the patient's clinical sample;

          (3) The isolated pathogen can cause the same disease symptoms after infecting the host animal. The patient's serum antibody titer during the recovery period increased four-fold, which can help identify the pathogen.

          Finding the nucleic acid, genomic and antibody evidence of the pathogen from the patient can be done in a short time. Scientific research, such as pathogen isolation and pathogenicity identification, can take weeks. The development of specific drugs and vaccines against a new pathogen may take years to complete. The expert group believes that the pathogen of this unexplained case of viral pneumonia is initially determined as a new type of coronavirus. The next step is to conduct expert research and judgement in combination with pathogenic research, epidemiological investigation and clinical manifestations.

          Coronaviruses are a group of pathogens that cause respiratory and intestinal diseases. There are many regularly arranged protrusions on the surface of this type of virus particle, and the entire virus particle is like an emperor's crown, hence the name "coronavirus". In addition to humans, coronaviruses can infect many mammals such as pigs, cattle, cats, dogs, marten, camels, bats, mice, hedgehogs, and various birds. So far, there are six known human coronaviruses. Four of these coronaviruses are more common in the population and are less pathogenic, generally causing only minor respiratory symptoms similar to the common cold. The other two coronaviruses—Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus, also known as SARS Coronavirus and MERS Coronavirus, can cause severe respiratory diseases. The new coronavirus that caused the epidemic is different from the human coronaviruses that have been discovered, and further understanding of the virus requires further scientific research. (CCTV reporter Shi Yingchun )
          http://m.news.cctv.com/2020/01/09/AR...96200109.shtml
          Twitter: @RonanKelly13
          The views expressed are mine alone and do not represent the views of my employer or any other person or organization.

          Comment


          • Experts Cast Doubts on Chinese Official Claims Around 'New' Wuhan Coronavirus

            2020-01-09
            .....Ho Pak-leung, head of the University of Hong Kong's Centre for Infection, has warned that it is highly possible that the illness is spreading from human to human, given the sheer number of cases that have mushroomed in a short period of time....

            Ren Ruihong, former head of the medical assistance department at the Chinese Red Cross, said she too has her doubts about the reported "absence" of human-to-human transmission in Wuhan.

            "It's a new type of mutant coronavirus," Ren said. "They haven't made public the genetic sequence, because it is highly contagious. From what I can tell, the patients caught it from other people. I have thought that all along."

            She said the lack of fatalities didn't indicate that the virus was less deadly than SARS, just that antiviral medications have improved in the past 10 years or so.

            Ren said she also regarded the relatively high number of infections in Hong Kong with suspicion, given that there had been no reports of cases anywhere in between the two cities, in the southern province of Guangdong, for example..
            ..https://www.rfa.org/english/news/chi...020133656.html
            CSI:WORLD http://swineflumagazine.blogspot.com/

            treyfish2004@yahoo.com

            Comment


            • Translation Google

              Author: Li Chenyang Ding Suya Source: Science China Press Published: 2020-1-10

              We are not panic in the face of Wuhan pneumonia epidemic

              ——Interview with Rao Zihe, Academician of the Chinese Academy of Sciences

              ■ Reporter Li Chenyang Intern Ding Suya

              On January 9, Xinhua News Agency reported that new progress has been made in the pathogenic identification of unexplained viral pneumonia in Wuhan. As of 21:00 on January 7, 2020, a new coronavirus was detected in the laboratory. The expert group believes that the pathogen of this unexplained case of viral pneumonia was initially identified as a new type of coronavirus.

              After the latest conclusion was released, the Chinese Science News interviewed Rao Zihe, an academician of the Chinese Academy of Sciences and a researcher at the Institute of Biophysics of the Chinese Academy of Sciences, to explain the series of coronavirus research.

              China Science News: After SARS in 2003, we have dealt with Coronavirus several times. What lessons can we learn from it?

              Rao Zihe: There are many types of coronaviruses that can infect humans and many animals. Prior to 2002, although coronavirus was a serious threat to the livestock industry, it was not harmful to humans and could cause the common cold that people are familiar with. But between 2002 and 2003, the SARS coronavirus triggered a severe pandemic of severe acute respiratory syndrome (commonly known as SARS).

              The natural host of SARS coronavirus in nature is actually a bat. Due to human activities or other accidental reasons, the virus transmitted from animals to humans and caused a major outbreak. Although new coronaviruses have been found intermittently since then, they do not appear to have triggered a major human epidemic.

              After 10 years of silence, MERS coronavirus has caused a Middle East respiratory syndrome outbreak in the Middle East. There are various signs that the natural host of MERS coronavirus may still be bats, but the outbreak was caused by camel transmission. This time, a new coronavirus has caused viral pneumonia in Wuhan.

              The fights with the coronavirus several times were caused by the virus that originally used wild animals as the host from animal to human. This reminds us that protecting the living environment of wild animals may be the best way to keep away from wild animal pathogens. It is very important to reduce the invasion of bats and other wild animal habitats, and to avoid close contact of these natural hosts with humans and animals.

              "China Science News": Around the scientific research of coronaviruses, what do scientists do in recent years?

              Rao Zihe: In response to major diseases caused by coronavirus, scientists have carried out a lot of research in epidemiology, pathogenic mechanism and prevention and treatment of infectious diseases in recent years.

              For example, it is found that the natural host of SARS virus and MERS virus in nature may be bats; the main receptors of SARS virus and MERS virus invading human cells were found to be ACE2 and DPP4 (also known as CD26), and then the virus surface proteins and human body were analyzed The three-dimensional spatial structure of the cell receptor complex clarifies the molecular mechanism of the virus invading cells; the three-dimensional spatial structure of key drug targets such as the coronavirus main protease is analyzed; a targeted broad-spectrum inhibitor is designed and developed; The mechanism of action of the inhibitor.

              These basic research work together with the prevention and control of infectious diseases have accumulated a lot of experience for us to deal with coronavirus. Therefore, after the appearance of the coronavirus, we were not as nervous and panic as we were during the SARS epidemic in 2003. Compared with 2003, our prevention system, scientific research system, and understanding of coronavirus are no longer comparable. We are more confident. Of course, one should not take it lightly, but continue to study.

              "China Science News": For the follow-up scientific research of coronavirus, what other aspects do you think should start from?

              Rao Zihe: Since 2003, the pace of development of coronavirus-based drugs has been slower, so that no effective drugs have been developed that can be marketed. Pharmaceutical companies may not have enough motivation to do the job. After taking the medicine, the disease is gone. Where can I put the medicine? Therefore, I believe that scientists should shoulder this responsibility.

              As a national scientific research institution, we should step up efforts to promote drug research and development in order to cope with the emergencies caused by coronavirus in the future.

              In fact, since 2003, our team has not relaxed the research on coronavirus, but has always been biting forward in this direction. At the same time, there are still a number of domestic research teams focusing on solving the problem of coronavirus.

              China Science News (2020-01-10 First Edition Highlights)

              http://news.sciencenet.cn/sbhtmlnews/2020/1/352728.shtm
              "Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear."
              -Nelson Mandela

              Comment


              • Wuhan's unexplained viral pneumonia patients can be controlled

                At the end of December 2019, a number of patients with unexplained viral pneumonia were confirmed in Wuhan. As of January 5, a total of 59 cases were confirmed. On January 9, 2020, the assessment expert group initially identified the unidentified pneumonia pathogen of Wuhan as a new coronavirus.

                Hu Ke, an expert in the medical treatment team for unexplained viral pneumonia in Wuhan and a professor of respiratory medicine at the Hubei Provincial People's Hospital, said on January 10 that most patients are currently mild to moderate. After treatment, the patient's condition can be controlled, and some of the patients who were initially admitted have been cured and discharged. Most of the other patients in the hospital are stable.
                Since the end of December 2019, Wuhan has confirmed a number of patients with unexplained viral pneumonia. As of January 5, 2020, a total of 59 cases have been confirmed. Some of these patients are operators of the South China Seafood Wholesale Market. On January 9, Xu Jianguo, the leader of the preliminary assessment of pathogen detection results and an academician of the Chinese Academy of Engineering, said that the expert group believes that the pathogen of this unexplained viral pneumonia case was initially identified as a new type of coronavirus.
                Hu Ke said that the main clinical manifestations of patients with unexplained viral pneumonia are mostly fever, fatigue, cough, and low sputum. Some patients have symptoms such as dyspnea as the disease progresses. Laboratory tests showed that the total number of white blood cells was normal or decreased in the early stage of onset, the lymphocyte count decreased, and some patients had elevated liver and muscle enzyme levels. Chest imaging showed multiple ground glassy exudates in the lungs.
                He said that by analyzing the collected data of patients with unexplained viral pneumonia, he found that the disease manifested as acute severe respiratory syndrome, mainly pneumonia. In the early stages of the disease, more than 90% have fever, about 80% have dry cough, more than 20% have chest tightness, about 20% have shortness of breath, and about 15% have dyspnea; about 80% of the cases have a normal or reduced white blood cell count, in all cases All had chest radiographic pneumonia.



                https://www.cn-healthcare.com/articl...nt-528579.html

                Comment


                • Wuhan New Coronavirus Related Science Popularization


                  A few days ago, regarding the progress of the pathogenic identification of the viral pneumonia epidemic of unknown cause in Wuhan, a reporter from Xinhua News Agency interviewed Xu Jianguo, the leader of the preliminary assessment of pathogenic test results and a member of the Chinese Academy of Engineering. He said that the expert group believed that the pathogen of this unexplained case of viral pneumonia was initially determined to be a new coronavirus. This article will be based on this interview for further scientific popularization.

                  Question 1: At present, what progress has been made in the pathogenic identification of unexplained viral pneumonia in Wuhan?


                  Xu Jianguo: As of 21:00 on January 7, 2020, a new coronavirus was detected in the laboratory, and the entire genome sequence of the virus was obtained. A total of 15 positive results of the new coronavirus were detected by nucleic acid detection methods. From 1 positive patient The virus was isolated from the samples and showed a typical coronavirus appearance under an electron microscope.
                  The expert group believes that the pathogen of this unexplained case of viral pneumonia was initially identified as a new type of coronavirus.

                  This article expands: discovering and identifying new viruses and determining the relationship between new viruses and diseases are the primary tasks for the prevention, diagnosis, and treatment of new-onset toxic infectious diseases. Traditionally, there are many methods for discovering new viruses, such as virus isolation, nucleic acid testing, serological tests, etc., but they all have certain limitations. High-throughput sequencing technology breaks through the limitations of traditional techniques and methods, and can directly take all genetic material in the specimen as the research object, so that it can quickly identify the virus present in the specimen.



                  Figure 1 Schematic diagram of macrotranscriptome sequencing based on shotgun method.
                  (A) Sample collection (B) Preliminary processing of samples (C) Extraction of nucleic acids from samples (D) Construction of sequencing libraries (E) High-throughput sequencing (F) Information analysis of sequencing sequences

                  Question 2: How is the pathogen identification carried out?


                  Xu Jianguo: The tissue laboratory used genomic sequencing, nucleic acid detection, virus isolation and other methods to perform pathogenic tests on patients' alveolar lavage fluid, throat swabs, blood and other samples.

                  This article expands: Genome sequencing generally first prepares samples and filters them, and then extracts the supernatant for RNA extraction. After the extracted RNA is removed from DNA and ribosomal RNA, the library is constructed by reverse transcription of random primers in vitro; sequencing Performed on second- or third-generation high-throughput sequencing platforms. Sequencing data is subjected to quality control, and the host genome sequence is removed for splicing. This pathogen identification should use both second- and third-generation sequencing platforms to obtain the entire genome sequence of the virus in a short period of time (this process takes 2-3 days).



                  Figure 2 Comparison of read length, accuracy, time, throughput, and cost of three generations of sequencing technology

                  After obtaining the whole genome sequence of the virus, primers can be designed to perform PCR reactions to detect the nucleic acid of the sample to determine whether the sample contains the virus's nucleic acid (this process can take 1 to 2 days). Alveolar lavage fluid, throat swabs, blood and other host-derived substances that contain viruses are called disease materials. Passage cell lines and primary cells are commonly used for isolation of viruses. Animal inoculation and chicken embryo inoculation can also be used for viruses when necessary. Separation. Viruses that have been successfully isolated are preferably expanded by cell culture. Animals, chicken embryos, and tissues can also be used for virus expansion and culture. Pure viruses after culture can be used for identification, typing, infection characteristics, and pathogenicity studies (this The process time is generally longer, but because of SARS experience, if it goes well, it will take 3-5 days).

                  Question 3: What procedures are needed to identify the pathogen?


                  Xu Jianguo: To confirm the cause of an epidemic disease, usually the following points must be met: (1) Suspicious pathogens must be found in patients, and pathogenic nucleic acids can be detected in clinical samples of patients; (2) From clinical samples of patients The pathogen can be successfully isolated; (3) The isolated pathogen can cause the same disease symptoms after infecting the host animal. The patient's serum antibody titer during the recovery period increased four-fold, which can help identify the pathogen.

                  Finding the nucleic acid, genomic and antibody evidence of the pathogen from the patient can be done in a short time. Scientific research, such as pathogen isolation and pathogenicity identification, can take weeks. The development of specific drugs and vaccines against a new pathogen may take years to complete.

                  This article expands: The research on the new virus has now completed the isolation of pathogens, and pathogenicity identification and the development of specific drugs and vaccines have just begun.

                  Question 4: What is the next step?


                  Xu Jianguo: The expert group believes that the pathogen of this unexplained case of viral pneumonia is initially determined as a new type of coronavirus. The next step is to conduct expert research and judgement in combination with etiology research, epidemiological investigation and clinical manifestations.

                  This article expands: Coronavirus is a single-stranded positive-stranded RNA virus with an envelope. It belongs to the coronavirus family Coronavirus in a systematic classification. It can infect humans, mice, pigs, cats, dogs, birds, and other vertebrates, and cause gastrointestinal Tract, respiratory and nervous system disorders. It has been over 70 years since the first coronavirus was first discovered and reported. However, since most members of this family did not cause serious human diseases in the past, and did not have important public health significance, Research has not received enough attention. The occurrence and epidemic of acute respiratory syndrome (SARS) in 2003 caused significant losses and serious threats to human life and health as well as the entire public health safety. There is evidence that bats are possible storage hosts. Therefore, the question of the source of infection has become a hot spot in the field of virology, and at the same time, it has made people re-understand the harm of coronavirus. Coronavirus is excreted through respiratory secretions, transmitted through oral fluid, sneeze, and contact, and transmitted through air droplets. The peak of infection occurs in autumn, winter, and early spring. The virus is sensitive to heat. Ultraviolet rays, lysol water, 0.1% peroxyacetic acid, and 1% liaoline can kill the virus in a short time.

                  The report of the International Committee of Classification of Virology divided the Coronaviridae into four genera, namely, genera alpha, beta, gamma and delta. Human coronavirus 229E and human coronavirus NL63 belong to the alpha genus, human coronavirus OC43, human coronavirus HPU1, and severe acute respiratory syndrome (SARS) belong to the beta genus. Generally, the phylogenetic tree is constructed by multiple alignment of the whole genome sequence, and the classification can be determined. There is no report on which new coronavirus belongs to it.

                  Question 5: What is a coronavirus?


                  Xu Jianguo: Coronavirus is a type of pathogen that mainly causes respiratory and intestinal diseases. There are many regularly arranged protrusions on the surface of this type of virus particle, and the entire virus particle is like an emperor's crown, hence the name "coronavirus". In addition to humans, coronaviruses can infect many mammals such as pigs, cattle, cats, dogs, marten, camels, bats, mice, hedgehogs, and various birds. So far, there are six known human coronaviruses. Four of these coronaviruses are more common in the population and are less pathogenic, generally causing only minor respiratory symptoms similar to the common cold. The other two coronaviruses—Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus, also known as SARS Coronavirus and MERS Coronavirus, can cause severe respiratory diseases. The new coronavirus that caused the epidemic is different from the human coronaviruses that have been discovered, and further understanding of the virus requires further scientific research.

                  This article expands: The entire genome of a coronavirus usually contains 7 open reading frames, with a spacer sequence between each two adjacent genes. The 5 'end is a non-coding region cap structure and the 3' end is a polyadenylic acid non-coding region. The 5 'end occupies about two-thirds of the entire genome. ORF1 (including ORF1a and 1b) is also known as the replicase gene, which is responsible for encoding more than 16 non-structural proteins related to viral replication; 4 open readings near the 3' end Box, which encodes S protein (spike protein), E protein (envelope protein), M protein (membrane protein), and N protein (nucleoprotein); there is also a non-structural protein NS3 between the S gene and the M gene. Coronaviruses can achieve "jump" from wild animals to human hosts by genetic recombination or mutation of the spinous protein (S) receptor binding region and cause diseases with high mortality, such as severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS). Although both SARS-CoV and MERS-CoV are derived from bats, they do not directly infect humans, but achieve their cross-species transmission through intermediate hosts.



                  Figure 3 Schematic diagram of the coronavirus genome
                  According to the current public information and data, it is still in a "distributed" state. "Dissemination" refers to sporadic occurrences and is not a popular condition. The SARS epidemic that year lasted for about two and a half months from the first outbreak of November 16, 2002 to the end of January of the following year. Different viruses have different evolutionary paths, and it is difficult to predict whether or when the Wuhan Pneumonia Virus will appear as a "super spreader". This time the virus originated in the seafood market, we can assume that a possible transmission path is: waterfowl-fish and shrimp-human.

                  Written by Li Jie, School of Biological and Food Engineering, Changshu Institute of Technology

                  Editor-in-chief: Liu Yongxin Institute of Genetic Development, Chinese Academy of Sciences

                  http://blog.sciencenet.cn/blog-3334560-1213545.html

                  Comment


                  • Source: https://sg.news.yahoo.com/new-suspec...102413784.html

                    Wuhan virus outbreak: New suspected case in Singapore, China male isolated
                    Staff Writer, Singapore Editorial Team
                    Yahoo News Singapore10 January 2020

                    SINGAPORE — A 26-year-old male Chinese national has been admitted for further assessment and treatment as part of precautions in light of a pneumonia outbreak in China, said the Ministry of Health (MOH) on Friday (10 January).

                    The ministry said that it was notified of the case of pneumonia as of 10am.

                    The man, who had travelled to Wuhan, has been isolated as a precautionary measure and remains in stable condition, it added.

                    “The suspect case has not visited the Huanan seafood wholesale market associated with the cluster of pneumonia in Wuhan,” the MOH said.

                    Investigations to establish whether the case is linked to the outbreak are ongoing.

                    Last Sunday, a three-year-old female Chinese national with pneumonia, who had also travelled to Wuhan, was similarly isolated as a precautionary measure...

                    Comment


                    • Source: http://m.xinhuanet.com/hb/2020-01/10/c_1125447388.htm

                      Google translation:
                      Experts say that more patients with unexplained viral pneumonia in Wuhan can be controlled
                      2020-01-10 20:16:25 Source: Xinhuanet


                      Xinhua News Agency, Wuhan, January 10th (Reporter Liao Jun, Li Changzheng) Hu Ke, an expert in the medical treatment team of unexplained viral pneumonia in Wuhan and a professor of respiratory medicine at the People's Hospital of Hubei Province, said on the 10th that most patients are mild to moderate . After treatment, the patient's condition can be controlled, and some of the patients who were initially admitted have been cured and discharged. Most of the other patients in the hospital are stable.

                      底 Since the end of December last year, Wuhan has confirmed multiple cases of unexplained viral pneumonia. As of January 5, a total of 59 cases have been confirmed. Some of these patients are operators of the South China Seafood Wholesale Market. On the 9th, Xu Jianguo, leader of the preliminary assessment of pathogen detection results and academician of the Chinese Academy of Engineering, said that the expert group believes that the pathogen of this unexplained viral pneumonia case was initially determined as a new type of coronavirus.

                      Hu Ke said that the main clinical manifestations of patients with unexplained viral pneumonia are mostly fever, fatigue, cough, and low sputum. Some patients have symptoms such as dyspnea as the disease progresses. Laboratory tests showed that the total number of white blood cells was normal or decreased in the early stage of onset, the lymphocyte count decreased, and some patients had elevated liver and muscle enzyme levels. Chest imaging showed multiple ground glassy exudates in the lungs.

                      He said that by analyzing the collected data of patients with unexplained viral pneumonia, he found that the disease manifested as acute severe respiratory syndrome, mainly pneumonia. In the early stages of the disease, more than 90% have fever, about 80% have dry cough, more than 20% have chest tightness, about 20% have shortness of breath, and about 15% have dyspnea; about 80% of the cases have a normal or reduced white blood cell count, in all cases All had chest radiographic pneumonia. (Finish)

                      Comment


                      • Originally posted by Shiloh View Post
                        Source: https://sg.news.yahoo.com/new-suspec...102413784.html

                        Wuhan virus outbreak: New suspected case in Singapore, China male isolated
                        Staff Writer, Singapore Editorial Team
                        Yahoo News Singapore10 January 2020

                        SINGAPORE — A 26-year-old male Chinese national has been admitted for further assessment and treatment as part of precautions in light of a pneumonia outbreak in China, said the Ministry of Health (MOH) on Friday (10 January).

                        The ministry said that it was notified of the case of pneumonia as of 10am.

                        The man, who had travelled to Wuhan, has been isolated as a precautionary measure and remains in stable condition, it added.

                        “The suspect case has not visited the Huanan seafood wholesale market associated with the cluster of pneumonia in Wuhan,” the MOH said.

                        Investigations to establish whether the case is linked to the outbreak are ongoing.

                        Last Sunday, a three-year-old female Chinese national with pneumonia, who had also travelled to Wuhan, was similarly isolated as a precautionary measure...
                        MoH statement -

                        UPDATE ON LOCAL SITUATION REGARDING SEVERE PNEUMONIA CLUSTER IN WUHAN

                        10TH JAN 2020

                        As of 10am, 10 January 2020, the Ministry of Health has been notified of a 26 year-old male Chinese national with pneumonia, who had travel history to Wuhan. He has been admitted for further assessment and treatment, and isolated as a precautionary measure. His condition is stable.


                        The suspect case has not visited the Huanan seafood wholesale market associated with the cluster of pneumonia in Wuhan.


                        Investigations to establish whether the suspect case is linked to the Wuhan pneumonia cluster are ongoing.


                        https://www.moh.gov.sg/news-highligh...n-wuhan-10-jan

                        Comment


                        • Originally posted by tetano View Post
                          Wuhan's unexplained viral pneumonia patients can be controlled

                          At the end of December 2019, a number of patients with unexplained viral pneumonia were confirmed in Wuhan. As of January 5, a total of 59 cases were confirmed. On January 9, 2020, the assessment expert group initially identified the unidentified pneumonia pathogen of Wuhan as a new coronavirus.

                          Hu Ke, an expert in the medical treatment team for unexplained viral pneumonia in Wuhan and a professor of respiratory medicine at the Hubei Provincial People's Hospital, said on January 10 that most patients are currently mild to moderate. After treatment, the patient's condition can be controlled, and some of the patients who were initially admitted have been cured and discharged. Most of the other patients in the hospital are stable.
                          Since the end of December 2019, Wuhan has confirmed a number of patients with unexplained viral pneumonia. As of January 5, 2020, a total of 59 cases have been confirmed. Some of these patients are operators of the South China Seafood Wholesale Market. On January 9, Xu Jianguo, the leader of the preliminary assessment of pathogen detection results and an academician of the Chinese Academy of Engineering, said that the expert group believes that the pathogen of this unexplained viral pneumonia case was initially identified as a new type of coronavirus.
                          Hu Ke said that the main clinical manifestations of patients with unexplained viral pneumonia are mostly fever, fatigue, cough, and low sputum. Some patients have symptoms such as dyspnea as the disease progresses. Laboratory tests showed that the total number of white blood cells was normal or decreased in the early stage of onset, the lymphocyte count decreased, and some patients had elevated liver and muscle enzyme levels. Chest imaging showed multiple ground glassy exudates in the lungs.
                          He said that by analyzing the collected data of patients with unexplained viral pneumonia, he found that the disease manifested as acute severe respiratory syndrome, mainly pneumonia. In the early stages of the disease, more than 90% have fever, about 80% have dry cough, more than 20% have chest tightness, about 20% have shortness of breath, and about 15% have dyspnea; about 80% of the cases have a normal or reduced white blood cell count, in all cases All had chest radiographic pneumonia.



                          https://www.cn-healthcare.com/articl...nt-528579.html
                          Also translated by:

                          Hayes Luk
                          @hayesluk

                          4h
                          According to Prof. Hu who is treating the Wuhan patient, he summarizes the symptom as follows 1. over 90% of patient has fever 2. ~80% has dry cough 3. ~20% has shortness of breath 4. ~ 15% has breathing difficulties

                          Comment


                          • No new updates on the Wuhan Municipal Health Commission site about this outbreak since January 5.
                            http://wjw.wuhan.gov.cn/front/web/list2nd/no/710

                            Nothing on the National Health Commission site.
                            http://www.nhc.gov.cn/

                            Is this one of those situations where the public is held in the dark because researchers are rushing to be the first one to publish a paper on an emerging disease?

                            Is the government hiding anything? Does anyone believe there is really no official news on this outbreak for 5 days?



                            FluTrackers.com
                            @FluTrackers

                            now
                            China - Can we have an update on the mystery pneumonia/coronavirus situation please? How many have now been screened? Hospitalized? Serious cases vs. mild? How many released & how many total contacts being followed?

                            Also - spread to new geographical areas?

                            Thanks!

                            The World.

                            Comment


                            • Source: https://hk.on.cc/hk/bkn/cnt/cnnews/2...52_001_cn.html

                              Google translation:
                              Wuhan pneumonia: Official confirmed 1 patient died, 7 were still seriously ill
                              January 11, 2020 07:00
                              The first death from pneumonia caused by a new coronavirus in Wuhan.
                              The outbreak of pneumonia caused by a new coronavirus in Wuhan City, Hubei has attracted national attention. The Wuhan Municipal Health Commission informed that as of 0:00 am on Saturday (11th), 41 cases of pneumonia were initially diagnosed with a new coronavirus infection, of which 2 have been discharged, 1 death and 7 severe cases. The remaining patients were in stable condition. This is the first official death confirmed by Wuhan pneumonia. As for the 739 people in close contact with the patients, they have all received medical observations, of which 419 were medical staff, and no related cases were found.
                              The report pointed out that after the preliminary determination of the "unknown viral pneumonia" pathogen as a new type of coronavirus, the national, provincial and municipal expert groups immediately revised and improved the pneumonia diagnosis and treatment, monitoring and other programs; Detection and completion of pathogenic nucleic acid detection. According to the patient's clinical manifestations, epidemiological history, and laboratory test results, experts corrected 41 cases of pneumonitis with new coronavirus infection, 18 fewer than the 59 previously reported.
                              The report emphasized that since last Friday (3rd), no new cases have been found in Wuhan, and no medical staff infection has been found, and there is no clear evidence of human-to-human transmission. Various departments in Wuhan have begun prevention and treatment work, including the full treatment of patients, in-depth epidemiological investigations, extensive publicity of disease prevention knowledge, cooperation with national and provincial etiological studies, and cooperation with the National Health Commission to notify the WHO of the epidemic information.















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                              • Government report:


                                Wuhan Municipal Health and Health Commission's Report on Unexplained Viral Pneumonia

                                Issuing authority: Wuhan City health committee | Published: 2020-01-11 07:04:11 | Hits: 3848 | Font Size: Da Zhong Small


                                After the pathogen of "unknown cause of viral pneumonia" was initially determined to be a new type of coronavirus, the national, provincial and municipal expert groups immediately revised and improved plans for diagnosis, treatment, and monitoring of unexplained viral pneumonia. The Wuhan Municipal Health and Health Committee has organized tests on existing patient specimens. As of 14:00 on January 10, 2020, pathogenic nucleic acid testing has been completed. The national, provincial and municipal expert groups comprehensively judged the clinical manifestations, epidemiological history, and laboratory test results of patients admitted to the hospital for treatment, and 41 cases of pneumonia with a new coronavirus infection were initially diagnosed, of which 2 were discharged, Seven cases were severe and one died. The remaining patients were in stable condition. All 739 close contacts, including 419 medical staff, have undergone medical observation and no related cases have been found.

                                Since the outbreak, with the support of the state and Hubei Province, Wuhan has cooperated with relevant departments to carry out the prevention and treatment in an orderly manner. First, we have tried our best to treat patients. Develop a diagnosis and treatment work plan, and effectively achieve early detection, early diagnosis, early isolation, and early treatment, and focus on experts and resources to give full treatment. The second is to carry out in-depth epidemiological investigations. The investigation found that the patients were mainly operating and purchasing staff of the South China Seafood Wholesale Market in Wuhan. On January 1, 2020, the South China Seafood Wholesale Market has been closed and measures have been taken to strengthen the prevention of disease and environmental hygiene in public places in the city, especially the farmers' market. management. The third is to widely publicize disease prevention knowledge and enhance public self-protection awareness. The fourth is to cooperate with the state and province to carry out pathogenic research. The fifth is to cooperate with the National Health and Health Commission to report the epidemic situation information to the World Health Organization in a timely manner.

                                No new cases have been detected since January 3, 2020. At present, no medical staff infections have been found, and no clear evidence of human-to-human transmission has been found. Our city will continue to strengthen patient treatment, epidemiological investigations, carry out in-depth patriotic health campaigns, do a good job in spreading knowledge of disease prevention, and safeguard the health of the people.

                                At present, it is in the season of high incidence of infectious diseases in winter and spring. The public must maintain indoor air circulation, try to avoid closed public places and crowded places, and wear masks if necessary. If you have fever, respiratory infection symptoms, especially persistent fever, go to a medical institution in time.





                                January 11, 2020


                                http://wjw.wuhan.gov.cn/front/web/sh.../2020011109035

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