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Open Forum Infect Dis . Three Years of the Coronavirus Disease 2019 Pandemic in a European Region: A Population-Based Longitudinal Assessment in Ma

tetano

Editor, Senior Moderator
Open Forum Infect Dis


. 2023 Dec 18;11(1):ofad635.
doi: 10.1093/ofid/ofad635. eCollection 2024 Jan. Three Years of the Coronavirus Disease 2019 Pandemic in a European Region: A Population-Based Longitudinal Assessment in Madrid Between 2020 and 2022

Juan Berenguer[SUP] 1 2 3 [/SUP], María J Calvo-Alcántara[SUP] 4 [/SUP], Alejandro Alvaro-Meca[SUP] 3 5 [/SUP], José C Estévez[SUP] 6 [/SUP], Miguel Basanta[SUP] 7 [/SUP], Sergio Ruiz[SUP] 6 [/SUP], Ángel L Matáix[SUP] 4 [/SUP], César Bienzóbas[SUP] 8 [/SUP], Lourdes Cosano[SUP] 1 [/SUP], Aura P Silva[SUP] 1 [/SUP], Pilar Salas[SUP] 1 [/SUP], Pedro Gullón[SUP] 9 [/SUP], Manuel Franco[SUP] 9 [/SUP], José R Arribas[SUP] 3 10 11 12 [/SUP], José M Molero[SUP] 13 [/SUP], Miguel A Hernán[SUP] 14 [/SUP]



Affiliations
Abstract

Background: Our objective was to assess the health impact of coronavirus disease 2019 (COVID-19) during 2020-2022 in the Madrid region.
Methods: We included all individuals registered in the Madrid Health System Registry as of 31 December 2019, and followed them until 31 December 2022. Using a unique personal identifier, we linked the databases of primary care, hospitals, pharmacies, certified laboratories performing diagnostic tests, vaccines, and mortality.
Results: Of 6 833 423 individuals, 21.4% had a confirmed COVID-19 diagnosis, and 1.5% had a COVID-19 hospitalization (primary diagnosis). Thirty-day mortality was 1.6% for confirmed COVID-19 (from 11.4% in first semester 2020 to 0.4% in first semester 2022). Thirty-day mortality was 10.8% for COVID-19 hospitalizations (from 14.0% in first semester 2020 to 6.0% in second semester 2022). There were 24 073 deaths within 30 days of a confirmed COVID-19 diagnosis. Advanced age, male sex, higher socioeconomic deprivation, and comorbidities were associated with higher mortality.
Conclusions: By linking administrative and clinical databases, we characterized the burden of the COVID-19 pandemic in Madrid over 3 years. Our analysis proposes a high-level framework for comparisons of the burden of COVID-19 across areas worldwide.

Keywords: COVID-19; SARS-CoV-2; coronavirus; population-based study.

 
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