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Cell Rep . Evolution of the SARS-CoV-2 Omicron spike

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  • Cell Rep . Evolution of the SARS-CoV-2 Omicron spike

    Cell Rep

    . 2023 Nov 17;42(12):113444.
    doi: 10.1016/j.celrep.2023.113444. Online ahead of print. Evolution of the SARS-CoV-2 Omicron spike

    Ruth J Parsons 1 , Priyamvada Acharya 2


    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern, first identified in November 2021, rapidly spread worldwide and diversified into several subvariants. The Omicron spike (S) protein accumulated an unprecedented number of sequence changes relative to previous variants. In this review, we discuss how Omicron S protein structural features modulate host cell receptor binding, virus entry, and immune evasion and highlight how these structural features differentiate Omicron from previous variants. We also examine how key structural properties track across the still-evolving Omicron subvariants and the importance of continuing surveillance of the S protein sequence evolution over time.

    Keywords: CP: Microbiology; Keywords: ◼.