Tweet
Emerg Infect Dis
. 2022 Dec;28(12):2500-2503.
doi: 10.3201/eid2812.220801.
Isolation of Bat Sarbecoviruses, Japan
Shin Murakami, Tomoya Kitamura, Hiromichi Matsugo, Haruhiko Kamiki, Ken Oyabu, Wataru Sekine, Akiko Takenaka-Uema, Yuko Sakai-Tagawa, Yoshihiro Kawaoka, Taisuke Horimoto
- PMID: 36417954
- DOI: 10.3201/eid2812.220801
Abstract
Surveillance of bat betacoronaviruses is crucial for understanding their spillover potential. We isolated bat sarbecoviruses from Rhinolophus cornutus bats in multiple locations in Japan. These viruses grew efficiently in cells expressing R. cornutus angiotensin converting enzyme-2, but not in cells expressing human angiotensin converting enzyme-2, suggesting a narrow host range.
Keywords: ACE2; Japan; Rhinolophus; SARS-CoV-2; SARS-related coronavirus; angiotensin converting enzyme-2; bat; betacoronavirus; coronaviruses; respiratory infections; sarbecovirus; severe acute respiratory syndrome coronavirus 2; virus isolation; viruses; zoonoses.