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Sci Rep . Association of COVID-19 with diabetes: a systematic review and meta-analysis

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  • Sci Rep . Association of COVID-19 with diabetes: a systematic review and meta-analysis


    Sci Rep


    . 2022 Nov 23;12(1):20191.
    doi: 10.1038/s41598-022-24185-7.
    Association of COVID-19 with diabetes: a systematic review and meta-analysis


    Paddy Ssentongo 1 2 , Yue Zhang 1 , Lisa Witmer 2 , Vernon M Chinchilli 1 , Djibril M Ba 3 4



    Affiliations

    Abstract

    Emerging evidence suggests that coronavirus disease-2019 (COVID-19) may lead to a wide range of post-acute sequelae outcomes, including new onset of diabetes. The aim of this meta-analysis was to estimate the incidence of newly diagnosed diabetes in survivors of COVID-19. We searched MEDLINE, Scopus, Cochrane Central Register of Controlled Trials and the World Health Organization Global Literature on Coronavirus Disease and clinical trial registries for studies reporting the association of COVID-19 and diabetes. Search dates were December 2019-October 16, 2022. Two investigators independently assessed studies for inclusion. Risk of bias was assessed using the Newcastle-Ottawa Scale. We estimated the effect of COVID-19 on incident diabetes by random-effects meta-analyses using the generic inverse variance method. We identified 8 eligible studies consisting of 4,270,747 COVID-19 patients and 43,203,759 controls. Median age was 43 years (interquartile range, IQR 35-49), and 50% were female. COVID-19 was associated with a 66% higher risk of incident diabetes (risk ratio, 1.66; 95% CI 1.38; 2.00). The risk was not modified by age, sex, or study quality. The median risk of bias assessment was 7. In this systematic review and meta-analysis, COVID-19 was associated with higher risk for developing new onset diabetes among survivors. Active monitoring of glucose dysregulation after recovery from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is warranted.


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