Announcement

Collapse
No announcement yet.

Med Virol . Dynamics of spreading of SARS-CoV-2 in a Belgian hemodialysis facility: the importance of the analysis of viral strains

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Med Virol . Dynamics of spreading of SARS-CoV-2 in a Belgian hemodialysis facility: the importance of the analysis of viral strains


    Med Virol


    . 2021 Nov 23.
    doi: 10.1002/jmv.27471. Online ahead of print.
    Dynamics of spreading of SARS-CoV-2 in a Belgian hemodialysis facility: the importance of the analysis of viral strains


    Laura Labriola 1 2 , Jean Ruelle 3 2 , Anaïs Scohy 3 4 , François Seghers 1 , Quentin Perlot 1 , Julien De Greef 5 , Christine Desmet 1 , Cécile Romain 1 , Jean Cyr Yombi 5 2 , Hector Rodriguez-Villalobos 3 4 , Benoît Kabamba 3 4 , Michel Jadoul 1 2



    Affiliations

    Abstract

    In-center maintenance hemodialysis (HD) patients are at high risk of acquiring COVID-19 by cross-contamination inside the unit. The aim of this study was to assess retrospectively the dynamics of SARS-CoV-2 transmission during the very first pandemic phase (March-July 2020) in a cohort of in-center maintenance HD patients and in nurses the same HD facility, using a phylogenetic approach. All SARS-CoV-2 RT-qPCR positive patients and nurses from our HD unit -respectively 10 out of 98, and 8 out of 58- and two other positive patients dialyzed in our self-care unit were included. Whole genome viral sequencing and phylogenetic analysis supported the cluster investigation. Five positive patients were usually dialyzed in the same room and same shift, before their COVID-19 diagnosis was made. Viral sequencing performed on 4/5 patients' swabs showed no phylogenetic link between their viruses. The fifth patient (whose virus could not be sequenced) was dialyzed at the end of the dialysis room and was treated by a different nurse than the one in charge of the other patients. Three nurses shared the same virus detected in both self-care patients (one of them had been transferred to our in-center facility). The epidemiologically strongly suspected intra-unit cluster could be ruled out by viral genome sequencing. The infection control policy did not allow inter-patient contamination within the HD facility, in contrast to evidence of moderate dissemination within the nursing staff and in the satellite unit. Epidemiologic data without phylogenetic confirmation might mislead the interpretation of the dynamics of viral spreading within congregate settings. This article is protected by copyright. All rights reserved.

    Keywords: Epidemiology; Genetic mapping; Genetics; Horizontal transmission; SARS coronavirus; Virus classification.

Working...
X