Open Forum Infect Dis . Nonpharmaceutical Interventions Remain Essential to Reducing Coronavirus Disease 2019 Burden Even in a Well-Vaccinated Society: A Modeling Study

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Open Forum Infect Dis


. 2021 Aug 9;8(9):ofab415.
doi: 10.1093/ofid/ofab415. eCollection 2021 Sep.
Nonpharmaceutical Interventions Remain Essential to Reducing Coronavirus Disease 2019 Burden Even in a Well-Vaccinated Society: A Modeling Study


Tomás M León ¹ , Jason Vargo ^{1 2} , Erica S Pan ¹ , Seema Jain ¹ , Priya B Shete ^{1 3}



Affiliations

• PMID: 34514021
• PMCID: PMC8419741
• DOI: 10.1093/ofid/ofab415

Abstract

Vaccination and nonpharmaceutical interventions (NPIs) reduce transmission of severe acute respiratory syndrome coronavirus 2 infection, but their effectiveness depends on coverage and adherence levels. We used scenario modeling to evaluate their effects on cases and deaths averted and herd immunity. NPIs and vaccines worked synergistically in different parts of the pandemic to reduce disease burden.

Keywords: COVID-19; California; NPIs; herd immunity; mathematical modeling; vaccination.