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Gene Rep . An overview of basic molecular biology of SARS-CoV-2 and current COVID-19 prevention strategies

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  • Gene Rep . An overview of basic molecular biology of SARS-CoV-2 and current COVID-19 prevention strategies


    Gene Rep


    . 2021 Apr 1;101122.
    doi: 10.1016/j.genrep.2021.101122. Online ahead of print.
    An overview of basic molecular biology of SARS-CoV-2 and current COVID-19 prevention strategies


    Ankur Das 1 , Raja Ahmed 1 , Suraiya Akhtar 1 , Khaleda Begum 1 , Sofia Banu 1



    Affiliations

    Abstract

    Coronavirus Disease 2019 (COVID-19) manifests as extreme acute respiratory conditions caused by a novel beta coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which is reported to be the seventh coronavirus to infect humans. Like other SARS-CoVs it has a large positive-stranded RNA genome. But, specific furin site in the spike protein, mutation prone and phylogenetically mess open reading frame1ab (Orf1ab) separates SARS-CoV-2 from other RNA viruses. Since the outbreak (February - March 2020), researchers, scientists, and medical professionals are inspecting all possible facts from every possible aspect including its replication, detection, and prevention strategies. This led to the prompt identification of its basic biology, genome characterization, structural and expression based functional information of proteins, and utilization of this information in optimizing strategies to prevent its spread. This review summarizes the recent updates on the basic molecular biology of SARS-CoV-2 and prevention strategies undertaken worldwide to tackle COVID-19. This recent information can be implemented for the development and designing of therapeutics against SARS-CoV-2.

    Keywords: AEC2, Angiotensin- converting enzyme 2; CD4 and CD8, Cluster of differentiation; CDC, Centres for Disease Control and Prevention; COVID-19, coronavirus diseases; GM-CSF, Macrophage colony-stimulating factor; Genome organization and expression; HCV, Hepatitis C virus; HIV, Human immune deficiency virus; LAMP, Loop mediated Isothermal Amplification; MARS-CoV, Middle East respiratory syndrome coronavirus; Prevention strategies; SARS-CoV-2; SARS-CoV2, severe acute respiratory syndrome coronavirus 2; WHO, World Health Organisation.

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