mLife . An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) - FluTrackers News and Information

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mLife . An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

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tetano

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Join Date: Dec 2009

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mLife . An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

May 5, 2026, 03:14 AM

mLife

. 2026 Mar 30;5(2):259-262.
doi: 10.1002/mlf2.12122. eCollection 2026 Apr.
An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

Lai Wei¹, Shuiqing Liu¹, Shanshan Lu¹, Shengdong Luo², Xiaoping An¹, Huahao Fan¹, Erguang Li³, Lihua Song¹

Affiliations
PMID: 42079448

PMCID: PMC13131323

DOI: 10.1002/mlf2.12122

Abstract

SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) is highly attenuated, but can cause mortality in a specifically designed human ACE2-transgenic mouse model, making it a surrogate model for evaluating the efficacy of vaccines and drugs against SARS-CoV-2.

© 2026 The Authors. mLife published by John Wiley & Sons Australia, Ltd on behalf of Institu

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