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https://journals.asm.org/doi/full/10.1128/JVI.02582-15
Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus
Authors: Xing-Lou Yang, Ben Hu, Bo Wang, Mei-Niang Wang, Qian Zhang, Wei Zhang, Li-Jun Wu, Xing-Yi Ge, Yun-Zhi Zhang, Peter Daszak, Lin-Fa Wang, Zheng-Li Shi https://orcid.org/0000-0001-8089-163XAuthors Info & Affiliations
DOI: https://doi.org/10.1128/JVI.02582-15
ABSTRACT
We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.
Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus
Authors: Xing-Lou Yang, Ben Hu, Bo Wang, Mei-Niang Wang, Qian Zhang, Wei Zhang, Li-Jun Wu, Xing-Yi Ge, Yun-Zhi Zhang, Peter Daszak, Lin-Fa Wang, Zheng-Li Shi https://orcid.org/0000-0001-8089-163XAuthors Info & Affiliations
DOI: https://doi.org/10.1128/JVI.02582-15
ABSTRACT
We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.