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  • SARS-CoV-2_variant-reports - GitHub

    Jan 19, 2023

    3 contributors:
    corneliusroemer
    rneher
    aretchless

    Variant report 2023-01-19

    China
    For the past month, China has been releasing around 200 sequences every week which is comparatively low. Using the number of recent sequences submitted per million inhabitants per month as a metric, China submits more than a 100 time less than large countries with high sequencing activity like US, UK, Japan, and 10x less than large countries with medium activity like Thailand, Indonesia, Brazil.

    A fourth China specific lineage has been given a Pango designation: BA.5.1.32. As the other 3 China-specific lineages, it is a BA.5 derivative, and like BA.5.2.48 and BA.5.2.49, it does not carry a single additional Spike mutation known to cause immune escape beyond those already found in BA.5.

    Sequences uploaded from China in the past two weeks are mostly BF.7.14 and BA.5.2.48, with BA.5.2.49 and BA.5.1.32 in the single digit percentage range. ...
    ______
    Variant report 2023-01-09

    3 Chinese clusters given Pango lineage names
    The 3 major Chinese lineages have now been given Pango names:
    • BA.5.2.48 is a BA.5.2 (on ORF1b:T1050N branch) with 4 additional silent nucleotide mutations: C2710T, C8626T, C16887T, T17208C; see designation issue #1471
    • BA.5.2.49 is a BA.5.2 (on ORF1b:T1050N branch) with ORF1b:S997P, S:T883I and silent nucleotide mutation A14673G; see designation issue #1480
    • BF.7.14 is a BF.7 (BA.5.2.1 with S:R346T) with extra S:C1243F, ORF1a:V274L, ORF1b:L238F, ORF7a:H47Y and silent nucleotide mutation C29632T; see designation issue #1470 ...
    ______
    Variant report 2023-01-06

    China
    Sequences submitted from Chinese labs and labeled as local cases continue to fall almost exclusively into lineages BA.5.2 and BF.7. No sequences with concerning mutation patterns have been submitted. ...
    ______
    Variant report 2022-12-22

    XBB.1.5 grows fast, in New York state and globally
    XBB.1.5 (XBB.1 + S:F486P), first mentioned in every report in this series since 2022-11-11 keeps growing fast and is predicted to be already dominant in New York state in samples collected on 2022-12-22. XBB.1.5 seems to grow by a factor of 2.2-2.5 every week (though these factors tend to decrease slightly as more data becomes available). A doubling per week compared to the average of circulating variants is still remarkable and on the order of Delta vs Alpha. ...



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