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Alterations in T and B cell function persist in convalescent COVID-19 patients

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  • Alterations in T and B cell function persist in convalescent COVID-19 patients

    NOTE: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

    Accepted: March 19, 2021
    Published:March 31, 2021
    DOI:https://doi.org/10.1016/j.medj.2021.03.013

    Halima A. Shuwa, Tovah N. Shaw, Sean B. Knight, Kelly Wemyss, Flora A. McClure, Laurence Pearmain, Ian Prise, Christopher Jagger, David.J. Morgan, Saba Khan, Oliver Brand, Elizabeth R. Mann, Andrew Ustianowski, Nawar Diar Bakerly, Paul Dark, Christopher E. Brightling, Seema Brij, CIRCO, Timothy Felton, Angela Simpson, John R. Grainger, Tracy Hussell, Joanne E. Konkel, Madhvi Menon

    Highlights
    • 1. Lymphocytes were examined during COVID-19 and at up to 6 months of convalescence
    • 2. B cell changes seen during acute COVID-19 were largely restored in convalescence
    • 3. T cells from convalescent COVID-19 patients displayed persistent changes
    • 4. Lymphocyte signatures defined 3 convalescent patient groups; one with poorer outcome
    Full Text in PDF Format:
    https://www.cell.com/action/showPdf?...2821%2900115-X
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