Announcement

Collapse
No announcement yet.

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

    See all authors and affiliations

    Science 15 Oct 2020:
    eabe9403
    DOI: 10.1126/science.abe9403

    Abstract

    The COVID-19 (Coronavirus disease-2019) pandemic, caused by the SARS-CoV-2 coronavirus, is a significant threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and MERS-CoV. Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analysis for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARS-CoV-2 Orf9b, an interaction we structurally characterized using cryo-EM. Combining genetically-validated host factors with both COVID-19 patient genetic data and medical billing records identified important molecular mechanisms and potential drug treatments that merit further molecular and clinical study.

    https://science.sciencemag.org/conte...medium=Twitter
Working...
X