Researchers trial new COVID-19 vaccine on pigs before human trials commence soon
by The Pig Site
30 March 2020, at 1:19pm
Working in collaboration, researchers from across the three institutions will begin testing new vaccines for their ability to induce protective antibodies against SARS-CoV-2 (COVID-19).
The vaccines will include the chimpanzee adenovirus vaccine vector (ChAdOx1) which is soon to enter human phase I clinical trials and has been used to create vaccines for diseases like Ebola, Middle Eastern respiratory syndrome (MERS) and flu.
The vaccine candidates developed at Oxford will contain the spike protein from SARS-CoV-2, the protein against which protective antibodies are generated in infected patients. Pirbright scientists will measure the level of antibodies produced after vaccination of pigs and assess whether the antibodies can block SARS-CoV-2 from infecting cells, thereby preventing infection.
Importantly, the pig immune system shares significant similarities to that of humans, so a good response to a vaccine in pigs will help to predict the success of vaccines for human use. Researchers will also test the safety of the new vaccines and monitor whether any adverse effects are observed in the pigs...
[link to thepigsite.com (secure)]
by The Pig Site
30 March 2020, at 1:19pm
Working in collaboration, researchers from across the three institutions will begin testing new vaccines for their ability to induce protective antibodies against SARS-CoV-2 (COVID-19).
The vaccines will include the chimpanzee adenovirus vaccine vector (ChAdOx1) which is soon to enter human phase I clinical trials and has been used to create vaccines for diseases like Ebola, Middle Eastern respiratory syndrome (MERS) and flu.
The vaccine candidates developed at Oxford will contain the spike protein from SARS-CoV-2, the protein against which protective antibodies are generated in infected patients. Pirbright scientists will measure the level of antibodies produced after vaccination of pigs and assess whether the antibodies can block SARS-CoV-2 from infecting cells, thereby preventing infection.
Importantly, the pig immune system shares significant similarities to that of humans, so a good response to a vaccine in pigs will help to predict the success of vaccines for human use. Researchers will also test the safety of the new vaccines and monitor whether any adverse effects are observed in the pigs...
[link to thepigsite.com (secure)]
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