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Proc Natl Acad Sci U S A. Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

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    Proc Natl Acad Sci U S A. Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells


    Proc Natl Acad Sci U S A. 2020 Mar 12. pii: 202002589. doi: 10.1073/pnas.2002589117. [Epub ahead of print]
    Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells.


    Matsuyama S1, Nao N2, Shirato K2, Kawase M2, Saito S3, Takayama I3, Nagata N4, Sekizuka T5, Katoh H2, Kato F2, Sakata M2, Tahara M2, Kutsuna S6, Ohmagari N6, Kuroda M5, Suzuki T4, Kageyama T3, Takeda M1.

    Author information




    Abstract

    A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently spreading across many countries globally. Here, we show that a TMPRSS2-expressing VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating and propagating SARS-CoV-2. Our results reveal that, in common with SARS- and Middle East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2.
    Copyright ? 2020 the Author(s). Published by PNAS.



    KEYWORDS:

    SARS-CoV-2; TMPRSS2; VeroE6; coronavirus; outbreak


    PMID:32165541DOI:10.1073/pnas.2002589117

    Tags: None
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