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J Med Virol. 2020 Mar 12. doi: 10.1002/jmv.25757. [Epub ahead of print] 2019 novel coronavirus patients' clinical characteristics, discharge rate and fatality rate of meta-analysis.
Li LQ1,2,3, Huang T1,2,3, Wang YQ4, Wang ZP5, Liang Y1,2,3, Huang TB1,2,3, Zhang HY1,2,3, Sun WM6, Wang YP2,3.
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Abstract
BACKGROUND:
To study the clinical data, discharge rate, and fatality rate of COVID-19 patients for clinical help.
METHODS:
The clinical data of COVID-19 patients from December 2019 to February 2020 were retrieved from four databases. We statistically analyzed the clinical symptoms and laboratory results of COVID-19 patients and explained the discharge rate, fatality rate with a single-arm meta-analysis.
RESULTS:
The available data of 1994 patients in 10 literatures were included in our study. The main clinical symptoms of COVID-19 patients were fever (88.5%), cough (68.6%), myalgia or fatigue (35.8%), expectoration (28.2%), dyspnea (21.9%). Minor symptoms include headache or dizziness: (12.1%) diarrhea (4.8%), nausea, and vomiting (3.9%). The results of laboratory results showed that the lymphocytopenia (64.5%), increase of CRP (44.3%), increase of LDH (28.3%), and leukocytopenia (29.4%) were more common.
CONCLUSIONS:
The results of single-arm meta-analysis showed that: the male took a larger percentage in the gender distribution of COVID-19 patients 60%[95%CI (0.54,0.65)], the discharge rate of COVID-19 patients was 42%[95%CI (0.29,0.55)], and the fatality rate was 7%[95%CI (0.04,0.10)]. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
2019-nCoV; COVID-19; clinical characteristics; discharge rate; fatality rate; meta-analysis
PMID: 32162702 DOI: 10.1002/jmv.25757