J Thromb Haemost. Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

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J Thromb Haemost. 2020 Feb 19. doi: 10.1111/jth.14768. [Epub ahead of print] Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia.

Tang N¹, Li D², Wang X¹, Sun Z¹.
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Abstract

BACKGROUND:

In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern.
OBJECTIVES:

To describe the coagulation feature of patients with NCP.
METHODS:

Conventional coagulation results and outcomes of consecutive 183 patients with confirmed NCP in Tongji hospital were retrospectively analysed.
RESULTS:

The overall mortality was 11.5%, the non-survivors revealed significantly higher D-dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P<0.05). 71.4% of non-survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay.
CONCLUSIONS:

The present study shows that abnormal coagulation results, especially markedly elevated D-dimer and FDP are common in deaths with NCP.
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KEYWORDS:

D-dimer; coagulation parameter; disseminated intravascular coagulation; fibrin degradation product; novel coronavirus pneumonia

PMID: 32073213 DOI: 10.1111/jth.14768