Announcement

Collapse
No announcement yet.

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

    https://www.sciencedirect.com/scienc...66354220300528
    The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

    Author:B. Coutard,C. Valle,X. de Lamballerie,B. Canard,N.G. Seidah,E. Decroly
    Publication:Antiviral Research
    Publisher:Elsevier
    Date:Available online 10 February 2020
    2020 Elsevier B.V. All rights reserved.

    Highlights

    •The genomic sequence of 2019-nCoV indicates that the virus clusters with betacoronaviruses of lineage b. •The protein sequence has a specific furin-like cleavage site absent in lineage b CoV, including SARS-CoV sequences. •The furin-like cleavage site may play a role in the viral life cycle and pathogenicity. •Campaigns to develop anti-2019-nCoV therapeutics should include the evaluation of furin inhibitors.
    “‘i love myself.’ the quietest. simplest. most powerful. revolution ever.” ---- nayyirah waheed

    Avatar: Franz Marc, Liegender Hund im Schnee 1911 (My posts are not intended as advice or professional assessments of any kind.)
Working...
X