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N Engl J Med. A Novel Influenza A (H1N1) Vaccine in Various Age Groups

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  • N Engl J Med. A Novel Influenza A (H1N1) Vaccine in Various Age Groups

    A Novel Influenza A (H1N1) Vaccine in Various Age Groups (NEJM, abstract, edited)
    Published at www.nejm.org October 21, 2009 (10.1056/NEJMoa0908535)

    A Novel Influenza A (H1N1) Vaccine in Various Age Groups

    Feng-Cai Zhu, M.D., Hua Wang, M.D., Han-Hua Fang, M.D., Jian Guo Yang, M.D., Xiao Jun Lin, M.D., Xiao-Feng Liang, M.D., Xue-Feng Zhang, M.D., Hong-Xing Pan, M.D., Fan-Yue Meng, M.D., Yue Mei Hu, M.D., Wen-Dong Liu, M.D., Chang-Gui Li, M.D., Wei Li, M.D., Xiang Zhang, M.D., Jin Mei Hu, M.D., Wei Bing Peng, M.D., Bao Ping Yang, M.D., Pei Xi, M.D., Hua-Qing Wang, M.D., and Jing-Shan Zheng, M.D.


    ABSTRACT

    Background
    There is an urgent need for a vaccine that is effective against the 2009 pandemic influenza A (H1N1) virus.

    Methods
    A split-virus, inactivated candidate vaccine against the 2009 H1N1 virus was manufactured, and we evaluated its safety and immunogenicity in a randomized clinical trial. Subjects were between 3 and 77 years of age, stratified into four age groups. The immunization schedule consisted of two vaccinations, 21 days apart. Subjects were injected with placebo or with vaccine, with or without alum adjuvant, at doses of 7.5 ?g, 15 ?g, or 30 ?g. Serologic analysis was performed at baseline and on days 21 and 35.

    Results
    A total of 2200 subjects received one dose, and 2103 (95.6%) received the second dose, of vaccine or placebo. No severe adverse side effects associated with the vaccine were noted. In the nonadjuvanted-vaccine groups, injection-site or systemic reactions, most mild in nature, were noted in 5.5 to 15.9% of subjects. Among the subjects receiving 15 ?g of nonadjuvanted vaccine, a hemagglutination-inhibition titer of 1:40 or more was achieved by day 21 in 74.5% of subjects between 3 and 11 years of age, 97.1% of subjects between 12 and 17 years, 97.1% of subjects between 18 and 60 years, and 79.1% of subjects 61 years of age or older; by day 35, the titer had been achieved in 98.1%, 100%, 97.1%, and 93.3% of subjects, respectively. The proportion with a titer of 1:40 or more was generally highest among the subjects receiving 30 ?g of vaccine, with or without adjuvant. Vaccine without adjuvant was associated with fewer local reactions and greater immune responses than was vaccine with adjuvant.

    Conclusions
    These data suggest that a single dose of 15 ?g of hemagglutinin antigen without alum adjuvant induces a typically protective immune response in the majority of subjects between 12 and 60 years of age. Lesser immune responses were seen after a single dose of vaccine in younger and older subjects.

    (ClinicalTrials.gov number, NCT00975572 [ClinicalTrials.gov] .)
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    <cite cite="http://content.nejm.org/cgi/content/full/NEJMoa0908535?query=TOC">NEJM -- A Novel Influenza A (H1N1) Vaccine in Various Age Groups</cite>
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  • #2
    Re: N Engl J Med. A Novel Influenza A (H1N1) Vaccine in Various Age Groups

    my summary:

    Chinese vaccine A/CA/7 study

    alum adjuvant not useful
    15% had pain , 15% had fever
    titers >1:40: in 3%,85%,96% after 0,1,2 doses
    I'm interested in expert panflu damage estimates
    my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

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